![CAS 2828433-10-7 [Sar9,Met(O2)11]-Substance P TFA](/uploads/48442/cas-2828433-10-7-sar9-met-o2-11-substance-p109c7.jpg)
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| CAS:2828433‑10‑7:[Sar9,Met(O2)11]‑Substance P TFA | |
| This peptide is a structurally optimized analog of native Substance P. Site modifications significantly improve its selectivity for NK1 receptors and metabolic stability. It binds and activates NK1 receptors with high specificity, inducing physiological and pathological effects such as smooth muscle contraction, pain signal transmission, neurogenic inflammation, and immune cell activation. After modification, its resistance to enzymatic degradation is enhanced, and the methionine sulfone structure avoids the problem of oxidative inactivation of native Substance P. It is a classic tool peptide for NK1 receptor functional verification in neuroscience and inflammation research. | |
| 95%/98%/99% | |
| C₆₃H₉₈N₁₈O₁₄S | |
| 1347.63, higher for TFA salt form | |
| Function Tags (comma-separated) | ||||||||
| [Sar9,Met(O2)11]-Substance P TFA | [Sar9,Met(O2)11]-Substance P TFA | NK1 receptor highly selective agonism, Neuroscience tool, Neurogenic inflammation, Pain research, Metabolically stable, Neuropeptide | Substance P homologous backbone with dual-site modifications for optimized receptor selectivity and antioxidant stability | 1346.73 | 1347.63 | Sarcosine substitution + methionine sulfone oxidation + C-terminal amidation |
| Long-term Storage | Short-term Storage | |||
| Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles | Stable for 2 weeks at 2-8℃ sealed & dry; ice pack shipping recommended | Stable for 7 days at 4℃; slow enzymatic degradation at room temperature, no risk of oxidative inactivation**Good water solubility, freely soluble in water and neutral physiological buffer**. Anti-enzymatic ability significantly better than native Substance P after modification | Stable for 2 years at -20℃ under dry & dark conditions |
| Applicable Research Areas (comma-separated) | ||||
| PEP-SUB001 | NK1 receptor highly selective agonist tool peptide with metabolic stability and oxidation resistance, for neural and inflammatory mechanism research | This peptide binds G protein-coupled NK1 receptors with high specificity, activates downstream phospholipase C / IP3 / DAG signaling pathway, increases intracellular calcium concentration, and mediates various biological effects: induces vascular endothelial relaxation, smooth muscle contraction, plasma extravasation; mediates pain signal transmission and modulation; induces mast cells and macrophages to release inflammatory mediators, participating in neurogenic inflammatory response. Compared with native Substance P, it has higher selectivity for NK1 receptors and extremely low cross-activity on NK2/NK3 receptors, and the Met(O2) modification solves the problem of oxidative inactivation of native methionine, with greatly improved metabolic stability. | Neurokinin 1 Receptor (NK1R); PLC/IP3/Ca²⁺ signaling pathway; Neurogenic inflammation and pain conduction pathway |
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